Relationship between organ damage and aldosterone concentration in hypertensive emergency

Role of aldosterone in various target organ damage in patients with hypertensive emergency: A cross-sectional study - Role of aldosterone in organ damage in patients with hypertensive emergency

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000055016

Enrollment

Registered

2024-07-19

Start date

2021-09-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypertensive emergency

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: During the period between April 2012 and August 2020, eighty-six patients visited the emergency department of Tokyo Bay Urayasu Ichikawa Medical Center, presenting with severe hypertension (systolicBP>180 mmHg and/or diastolic BP>120 mmHg) and the associated complications.

Exclusion criteria

Exclusion criteria: Among them, eighteen patients were transferred to other hospitals for further assessment and the treatment of severe hypertension. Of 68 patients admitted to our hospital, five patients died upon admission (i.e., before detailed evaluation); the causes of the death were brainstem hemorrhage (n=4) and aortic dissection (n=1). Ultimately, 63 patients were eligible for further evaluation.

Design outcomes

Primary

Measure	Time frame
Hypertensive target organ damage was evaluated on admission, including severe kidney impairment (eGFR less than 30 mL/min/1.73 m2, SKI), severe retinopathy, concentric left ventricular hypertrophy (c-LVH), thrombotic microangiopathy (TMA), heart failure with reduced ejection fraction (HFrEF) and cerebrovascular disease. Then, whether each organ injury was associated with blood pressure or a plasma aldosterone concentration was analyzed.	—

Measure

Time frame

Hypertensive target organ damage was evaluated on admission, including severe kidney impairment (eGFR less than 30 mL/min/1.73 m2, SKI), severe retinopathy, concentric left ventricular hypertrophy (c-LVH), thrombotic microangiopathy (TMA), heart failure with reduced ejection fraction (HFrEF) and cerebrovascular disease. Then, whether each organ injury was associated with blood pressure or a plasma aldosterone concentration was analyzed.

—

Countries

Japan

Contacts

Public ContactAkihiro Miyake

Tokyo Bay Urayasu Ichikawa Medical Center Department of Nephrology, Endocrinology & Diabetes

akihiro.miyake19@gmail.com0473513101

Outcome results