A Study on the Efficacy of Synthetic MRI in Evaluating the Severity of Alzheimer's Disease, Anti-Amyloid Beta Treatment Effects , and Treatment-Related Complications

A Study on the Efficacy of Synthetic MRI in Evaluating the Severity of Alzheimer's Disease, Anti-Amyloid Beta Treatment Effects , and Treatment-Related Complications - The evaluation of the treatment effects of Alzheimer's disease using Synthetic MRI

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000054968

Enrollment

Registered

2024-07-31

Start date

2024-03-12

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer&#39

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: This study enrolls patients over 20 years old diagnosed Alzheimer's disease according to the NIA-AA diagnostic criteria (2011).We assign patients who are eligible for receiving anti-Amyloid beta therapy, lecanemab or donanemab, and agree to continuous follow-up while receiving drug to the Anti-Amyloid Beta-treated group, and patients who are not eligible for receiving anti-amyloid beta treatment but agree to continuous follow-up to the non-Anti-Amyloid Beta-treated group.

Exclusion criteria

Exclusion criteria: We exclude patients in both groups who have contraindications for MRI imaging and are therefore unable to undergo continuous MRI imaging assessments, or are determined to be ineligible for this study by the principal investigator for any reason.

Design outcomes

Primary

Measure	Time frame
The primary outcome is to assess changes in brain volume over time by analyzing data from Synthetic MRI	—

Secondary

Measure	Time frame
The secondary outcome is to check whether ARIA develops, and examine the time to ARIA onset and its severity.	—

Countries

Japan

Contacts

Public ContactYuki Morita

Shinshu university Hospital Neurology and Rheumatology

yuki-m@shinhu-u.ac.jp0263-37-2673

Outcome results