Effect of inhalation pure Oxygen under Hyperbaric environment to saliva secretion, saliva components, and oral microbiome

Cohort study to evaluate the effect of inhalation pure oxygen under Hyperbaric environment to saliva secretion, saliva components, and oral microbiome - Effect of inhalation pure oxygen under Hyperbaric environment to saliva secretion, saliva components, and oral microbiome

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000054875

Enrollment

Registered

2024-07-05

Start date

2024-11-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adults

Interventions

Inhalation pure oxygen under Hyperbaric environment at 2.5 atmospheres for 10 days (2 hours per day)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 18 years or older of healthy adults

Exclusion criteria

Exclusion criteria: Dental and oral problem Jaw function problem Pneumothorax Chronic thromboembolic pulmonary disease Cardiopulmonary dysfunction

Design outcomes

Primary

Measure	Time frame
Saliva and dental plaque are collected at just after, 24h after, 1/2/3/4 week after intervention, and evaluate the items below. saliva secretion saliva buffer capacity IgA, beta-defensin2, LL-37 of saliva oral microbiome	—

Countries

Japan

Contacts

Public ContactKairi Hayashi

Institute of Science Tokyo masticatory function and health science

k.hayashi.spmd@tmd.ac.jp0358035227

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Sep 19, 2026