Effect of Gastroesophageal Reflux Disease (GERD) in Esophageal Cancer

Effect of Gastroesophageal Reflux Disease (GERD) in Esophageal Cancer - Effect of Gastroesophageal Reflux Disease (GERD) in Esophageal Cancer

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000054834

Enrollment

300

Registered

2024-07-01

Start date

2024-05-29

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with esophageal cancer and gastroesophageal reflux disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The applicant must satisfy all of the following 1) to 3). 1) Patients who have undergone esophageal pH/impedance test, esophageal endopressure test, and endoscopy at the Department of Gastroenterology, Chiba University Hospital. 2) Patients who have been diagnosed with esophageal cancer (adenocarcinoma or squamous cell carcinoma). 3) Patients who have received a full explanation of their participation in this study, and who have given written consent of their own free will based on full understanding.

Exclusion criteria

Exclusion criteria: 1) Those who have expressed their refusal to participate in this research through the information disclosure document 2) Other persons deemed unsuitable by the principal investigator.

Design outcomes

Primary

Measure	Time frame
Presence or absence of gastroesophageal reflux disease. Factors to be considered: Questionnaire (presence or absence of gastroesophageal reflux symptoms), esophageal pH and impedance testing (Acid exposure time [AET], reflux frequency [acid, weak acid, alkaline reflux], post-reflux swallow-induced peristaltic wave [PSPW] index, baseline impedance value [MNBI], proximal extent frequency, DeMeester score, acid clearance time, Bolus clearance time), esophageal manometry (presence of esophageal motility disorders [EMDs], IRP value, DCI value EGJ type, EGJ-CI value)	—

Measure

Time frame

Presence or absence of gastroesophageal reflux disease. Factors to be considered: Questionnaire (presence or absence of gastroesophageal reflux symptoms), esophageal pH and impedance testing (Acid exposure time [AET], reflux frequency [acid, weak acid, alkaline reflux], post-reflux swallow-induced peristaltic wave [PSPW] index, baseline impedance value [MNBI], proximal extent frequency, DeMeester score, acid clearance time, Bolus clearance time), esophageal manometry (presence of esophageal motility disorders [EMDs], IRP value, DCI value EGJ type, EGJ-CI value)

—

Secondary

Measure	Time frame
Factors affecting esophageal cancer. Factors to be considered: patient background (age, gender, BMI, drinking history, smoking history, presence of flasher, family history, presence of H. pylori infection), endoscopy (grade classification by Lugol's spray, presence of atrophic gastritis, Hill grade, presence of hiatal hernia), blood test (ALDH2)	—

Countries

Japan

Contacts

Public ContactTomomi Ozaki

Chiba University Hospital Gastroenterology

ozaki.tomomi@chiba-u.jp43222717

Outcome results