Non-invasive identification of high-risk plaques in non-culprit lesions of acute coronary syndrome

Non-invasive identification of high-risk plaques in non-culprit lesions of acute coronary syndrome - Non-invasive identification of high-risk plaques in non-culprit lesions of acute coronary syndrome

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000054809

Enrollment

100

Registered

2024-06-30

Start date

2023-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute coronary syndrome

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) patients were admitted with ACS (ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, and unstable angina pectoris); (2) intermediate stenosis in non-culprit lesions on coronary angiography or CCTA; (3) NIRS-IVUS evaluation for intermediate stenosis after percutaneous coronary intervention; and (4) each non-culprit lesion was evaluated using CCTA and FFRCT performed within a duration of 14 days between CT and percutaneous coronary intervention.

Exclusion criteria

Exclusion criteria: (1) chronic kidney disease as shown by an estimated glomerular filtration rate <30 ml/min/1.73 m2; (2) presentation with hemodynamic instability; (3) severe valvular heart diseases, (4) left main trunk lesions; (5) lesions that could not be evaluated by NIRS-IVUS for any reason (e.g., tortuous vessels, severe stenosis, and calcification that made catheter passage difficult); and (6) poor image quality that resulted in an inability to perform CCTA or NIRS-IVUS analysis.

Design outcomes

Primary

Measure	Time frame
Correlation between maxLCBI4mm values as indicated by NIRS-IVUS and plaque density,remodeling index, presence of microcalcification and napkin ring sign as assessed by CCTA and difference between FFR-CT proximal and distal to the stenosis (delta-FFR-CT) in non-responsive lesions	—

Countries

Japan

Contacts

Public ContactKazuyoshi Kakehi

Kindai University Faculty of Medicine Division of Cardiology

kakehi324@yahoo.co.jp81-72-366-0221

Outcome results