Major depressive disorder
Conditions
Interventions
None listed
Sponsors
Fujita Health University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients diagnosed with major depressive disorder according to DSM-5 criteria by a psychiatrist Patients with moderate to severe depressive symptoms who have not responded to adequate doses and duration of antidepressant therapy during the current episode
Exclusion criteria
Exclusion criteria: Patients with psychotic features, bipolar disorder, mild depressive episodes, persistent depression Patients with active suicidal ideation Patients with ferromagnetic implants in the upper body (cardiac pacemakers, cochlear implants, ferromagnetic intracranial aneurysm clips, and deep brain stimulation) Patients who have received rTMS therapy in the current episode Patients with residual affective disorders due to psychoactive substance use and polypharmacy Patients with a diagnosis of dementia, organic or symptomatic psychiatric disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in HAMD-17 score from baseline to endpoint | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in MADRS score from baseline to endpoint Change in PHQ-9 score from baseline to endpoint Response rate and remission rate at 3 and 6 weeks | — |
Countries
Japan
Contacts
Public ContactYuki Matsuda
Fujita Health University Department of Development and Education of Clinical Research
Outcome results
None listed