Werner syndrome
Conditions
Interventions
Speech and continuous vowel speech data of Werner syndrome patients who agree to participate in the study reading specific scripts will be recorded and coded. The data will be coded and analyzed by an
Sponsors
Department of Endocrinology, Hematology and Gerontology Chiba University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The subjects will be cases who are attending or hospitalized at Chiba University Hospital, as well as cases requested by other hospitals or the patients themselves, and who, with their consent, can make voice recordings and provide voice data on Werner syndrome, suspected cases, and blood-related family members. As a negative control, voice data from patients with diseases other than Werner syndrome and healthy individuals will also be included. However, existing voice data other than those for Werner syndrome will be used instead of acquiring new voice data. For this reason, we will use speech data from publicly available databases and a textbook on speech disorders published by the Japanese Association of Speech-Language Pathologists to compare speech sounds with those of normal subjects and those of other diseases that cause hoarseness.
Exclusion criteria
Exclusion criteria: Those who could not give consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences from the physician's subjective diagnostic establishment of hoarseness (80%); does Jitter show abnormal values in more than 80% of cases?" The voice data will be analyzed, its characteristics and features will be determined, and the above will be compared between two groups, Werner syndrome and normal subjects. Jitter (primary periodic fluctuation index) is a parameter of the disturbance of vocal fold vibration cycles. It is calculated by dividing the average difference between adjacent cycles' cycles by the average value of the overall cycle. The larger the value, the more frequent the grazing, but it has been reported to be an objective and reproducible indicator of hoarseness. Among the primary endpoints of the diagnostic criteria for this disease, abnormal voice, which is judged subjectively by the physician, is found in more than 80% of cases. Therefore, we hypothesized that Jitter, an objective index, may show abnormal values in more than 80% of cases and aimed to examine whether Jitter abnormalities could be a diagnostic aid in diagnosing this disease. | — |
Countries
Japan
Contacts
Public ContactMasaya Koshizaka
Chiba University Center for Preventive Medical Sciences
Outcome results
None listed