Prospective Study on the Efficacy of Avatrombopag Maleate Administration for Biliary Procedures in Chronic Liver Disease Patients with Thrombocytopenia

Prospective Study on the Efficacy of Avatrombopag Maleate Administration for Biliary Procedures in Chronic Liver Disease Patients with Thrombocytopenia - APBT Study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000054697

Enrollment

Registered

2024-07-01

Start date

2024-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

obstructive jaundice

Interventions

endoscopic biliary procedures:EST,EUS-BD

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Presence of chronic liver disease Platelet count less than 50000 per microliter Age at registration is 18 years or older and less than 90 years Written informed consent for participation in the study has been obtained from the study subject themselves

Exclusion criteria

Exclusion criteria: Platelet count greater than or equal to 50000 per microliter Cases with current pregnancy Cases with severe complications in other organs : ASA classification of 3 or higher (including dialysis patients) ECOG performance status 4 Patients in a moribund state with a life expectancy of less than 3 months Other cases deemed unsuitable by the principal investigator or co-investigator as study subjects

Design outcomes

Primary

Measure	Time frame
The presence or absence of post-procedural bleeding after endoscopic treatment: For cases undergoing EST (Endoscopic Sphincterotomy) or EUS-BD (Endoscopic Ultrasound-Guided Biliary Drainage), the presence of bleeding will be confirmed on the day after the procedure, 3 days after, and 7 days after. Post-procedural bleeding is defined as a decrease in Hb by 2 g/dL or more, or the presence of overt symptoms such as melena or hematemesis.	—

Measure

Time frame

The presence or absence of post-procedural bleeding after endoscopic treatment: For cases undergoing EST (Endoscopic Sphincterotomy) or EUS-BD (Endoscopic Ultrasound-Guided Biliary Drainage), the presence of bleeding will be confirmed on the day after the procedure, 3 days after, and 7 days after. Post-procedural bleeding is defined as a decrease in Hb by 2 g/dL or more, or the presence of overt symptoms such as melena or hematemesis.

—

Secondary

Measure	Time frame
Severity of Post-Procedure Bleeding and Other Complications After Endoscopic Treatment	—

Countries

Japan

Contacts

Public ContactAtsushi Okuda

Osaka Medical and Pharmaceutical University 2nd department of internal medicine

atsushi.okuda@ompu.ac.jp0726831221

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026