A Multi-Institutional Prospective Cohort Study of Surgical Treatment of Acquired Lacrimal Duct Obstruction

A Multi-Institutional Prospective Cohort Study of Surgical Treatment of Acquired Lacrimal Duct Obstruction - A Multi-Institutional Prospective Study of Surgery for Acquired Lacrimal Duct Obstruction

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000054685

Enrollment

300

Registered

2024-07-01

Start date

2025-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acquired lacrimal duct obstruction

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with acquired lacrimal duct obstruction, with symptoms associated with lacrimal duct obstruction such as epiphora, discharge, and blurred vision, and who are willing to undergo surgical treatment. Patients who do not wish to undergo surgical treatment but who give their consent to participate in this study. 2. Patients at least 18 years old and with written consent to participate in this study have been obtained.

Exclusion criteria

Exclusion criteria: 1. Patients with stenosis of the lacrimal punctum alone 2. Patients with endoscopic lacrimal duct intubation to prevent lacrimal duct obstruction caused by anticancer drugs 3. Patients with lacrimal duct obstruction caused by the tumor 4. Patients whose tear flow symptoms are thought to be caused by secretory tear flow, such as eyelid disease or keratoconjunctival disease, or by conductive tear flow other than lacrimal duct obstruction, or who are difficult to distinguish from other types of tear flow 5. Patients with congenital malformation syndrome, developmental delay, or congenital facial dysplasia 6. Other patients who are deemed by the physician in charge to be difficult to participate in the study

Design outcomes

Primary

Measure	Time frame
Anatomical and functional success rates for ELDR and DCR	—

Secondary

Measure	Time frame
1 Comparison of surgical success rates by obstruction site 2 Percentage of each treatment selection 3 Patient satisfaction 4 Impact on QOL 5 Comparison of surgical invasiveness 6 Hospitalization period 7 Quantitative evaluation of pre-and postoperative changes in tear fluid volume 8 Ratio of intraoperative and postoperative complications 9 Prevalence of lacrimal drainage system concretions 10 Rate of spontaneous healing in the absence of surgical treatment 11 Adverse events	—

Measure

Time frame

1 Comparison of surgical success rates by obstruction site 2 Percentage of each treatment selection 3 Patient satisfaction 4 Impact on QOL 5 Comparison of surgical invasiveness 6 Hospitalization period 7 Quantitative evaluation of pre-and postoperative changes in tear fluid volume 8 Ratio of intraoperative and postoperative complications 9 Prevalence of lacrimal drainage system concretions 10 Rate of spontaneous healing in the absence of surgical treatment 11 Adverse events

—

Countries

Japan

Contacts

Public ContactTomoyuki Kamao

Ehime University Graduate School of Medicine Department of Ophthalmology & Regenerative Medicine

t-kamao@m.ehime-u.ac.jp089-960-5361

Outcome results