Healthy volunteers
Conditions
Interventions
Administration of a rosmarinic acid-containing supplement and MRI imaging
Sponsors
Department of Neuropsychiatry, Keio University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Healthy individual 2.Having the capacity to consent (as it is necessary for the research subjects to have a full understanding of the study) 3.Being 18 years old or older, and under 45 years old
Exclusion criteria
Exclusion criteria: 1.Diagnosed with a mental disorder according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, Text Revision (DSM-5-TR) 2.Pregnant or breastfeeding women 3.History of physical dysfunction such as liver, kidney, or heart issues 4.Allergies to herbs, supplements, or polyphenols 5.Smokers 6.Currently taking medication 7.Having an implanted metal device such as a pacemaker (for safety reasons) 8.Head, neck, or body size not suitable for the MRI scanner (for safety reasons) 9.Having a tattoo larger than a one-point size, including tattoos and permanent makeup (for safety reasons) 10.Severe claustrophobia (for safety reasons)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in brain GABA concentration before and after administration of a rosmarinic acid-containing supplement, measured by MRS imaging. | — |
Countries
Japan
Contacts
Public ContactHiroyuki Uchida
Keio University School of Medicine Department of Neuropsychiatry
Outcome results
None listed