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The effect of different doses of paroxetine in premature ejaculation: a prospective randomized cross-over clinical trial

The effect of different doses of paroxetine in premature ejaculation: a prospective randomized cross-over clinical trial - The effect of different doses of paroxetine in premature ejaculation: a prospective randomized cross-over clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000054623
Enrollment
140
Registered
2024-06-11
Start date
2024-07-16
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

male sexual dysfunction

Interventions

group 1 will receive 12.5 mg paroxetine daily for 2 months then gradual tapering for 2 weeks then a 2 week washout period group 2 will receive 20 mg paroxetine daily for 2 months then gradual tapering

Sponsors

Kasr alainy cairo university
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: The patients married for at least 1 year with stable and continuous marital relationship. They will be asked not to use condoms, topical anaesthetic cream or spray before sexual intercourse. They will be presented with lifelong PE (intravaginal latency time <2??in) and inability to satisfy their partners. None of them had any formal psychosexual counselling.

Exclusion criteria

Exclusion criteria: Patients with erectile dysfunction (men having International Index of Erectile Function (IIEF) score (validated Arabic version) <21), reduced sexual desire or inhibited male orgasm were excluded from the study. In addition, patients with presence of mental disorders, physical illnesses affecting ejaculatory function, abuse of alcohol or recreational drugs and any psychotropic medications that may affect response to SSRIs or any medical treatment for premature ejaculation in the past 6 months were also excluded. Also, patients with urinary tract infection will be excluded.

Design outcomes

Primary

MeasureTime frame
evaluating the effect of different doses of Paroxetine in premature ejaculation

Secondary

MeasureTime frame
safety profile and complications of different doses of Paroxetine in premature ejaculation

Countries

Africa

Contacts

Public ContactSameh GamalEl Din

Cairo University Andrology & STDs

samehfayek@kasralainy.edu.eg0020729584

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026