Dental and Oral Surgical Diseases
Conditions
Interventions
None listed
Sponsors
Okayama University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients undergoing general anesthesia at the Department of Dental Anesthesiology, Okayama University Hospital between the date of approval by the director of the research institution and December 31, 2026. 2. Patients who are able to obtain free and voluntary written consent for participation in the study 3. Patients scheduled for total intravenous anesthesia with remimazolam and remifentanil 4. Patients who are at least 18 years old and less than 50 years old at the time of obtaining consent 5. Patients whose Body Mass Index (BMI) is less than 30 6. Patients whose general condition is PS-1 or PS-2 on the American Society of Anesthesiologists Preoperative Status Classification (ASA-PS). 7. Patients whose scheduled anesthesia time is less than 4 hours. 8. Patients scheduled for dental procedures or minimally invasive oral surgery such as tooth extraction. 9. Patients who are not considered to require narcotic analgesics for postoperative analgesia.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to remimazolam, remifentanil, or rocuronium 2. Patients requiring preanesthetic medication 3. Other patients deemed inappropriate for participation in the study by the principal investigator and research coordinators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Remimazolam blood concentration at various time points after completion of remimazolam administration | — |
Secondary
| Measure | Time frame |
|---|---|
| - Patient information: age, weight, height, BMI, gender, medical history, medications, and laboratory test results - Surgical information: operation details, operation time, anesthesia time - Time from the end of remimazolam administration to extubation (awake time) - Blood concentration of CNS7054 at each time point after completion of remimazolam administration - Pharmacokinetic parameters such as AUC (area under the blood concentration-time curve) of remimazolam and CNS7054 - BIS values at the end of remimazolam and at the time of extubation or flumazenil administration - Remimazolam total dose, average rate of administration - Remifentanil total dose, mean rate of administration - BIS values before anesthetic administration, during loss of consciousness, and during maintenance of anesthesia - Time from remimazolam administration to loss of consciousness - Number of bolus doses of remimazolam | — |
Countries
Japan
Contacts
Public ContactHitoshi Higuchi
Okayama University Hospital Department of Dental Anesthesiology
Outcome results
None listed