A verification study on the effects of a beverage containing the probiotic Lactococcus 11/19-B1 on nasal mucociliary clearance function and immune activation.

A verification study on the effects of a beverage containing the probiotic Lactococcus 11/19-B1 on nasal mucociliary clearance function and immune activation: a randomized, double-blind, placebo-controlled, parallel-group study. - A verification study on the effects of Lactococcus 11/19-B1 on nasal mucociliary clearance function and immune activation: a randomized, double-blind, placebo-controlled, parallel-group study.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000054577

Enrollment

Registered

2024-06-05

Start date

2024-05-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adults

Interventions

The volunteers are treated for four weeks with a 100 mL drink containing Lactococcus 11/19-B1 (10 billion bacterial cells/100 mL) once daily. The volunteers are treated for four weeks with a 100 mL dr

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. The individuals who are considered as appropriate for the study by the physician. 2. Within 1, those with low mucociliary clearance function in the nasal are preferentially selected.

Exclusion criteria

Exclusion criteria: 1. Subjects who have a current or past history of serious illness. 2. Subjects who regularly consume commercially available drugs, quasi-drugs, supplements, foods for specified health uses, and foods with functional claims. 3. Subjects with a current or past history of drug or food allergies. 4. Subjects who have donated component blood or 200 mL of whole blood within one month of the start of this study. 5. Subjects who have donated 400 mL of whole blood within 4 months of the start of this study. 6. Subjects who have participated in or are currently participating in other clinical trials or research within one month before obtaining consent or those who plan to participate during the study period. 7. Subjects who are currently pregnant or breastfeeding or those who wish to become pregnant during the study period. 8. Subjects who drink a lot of alcohol daily (60g/day in terms of alcohol). 9. Subjects with irregular lifestyles, such as those with extremely irregular eating habits, those who work shifts, or those who work late at night. 10. Subjects judged by the study director to be unsuitable for participation in this study. 11. Subjects with a smoking habit within the past 2 years.

Design outcomes

Primary

Measure	Time frame
Nasal mucociliary clearance time(saccharin tests)	—

Secondary

Measure	Time frame
Blood natural killer (NK) cell activity, blood cytokine levels, blood biochemical parameters, self-reported throat discomfort (irritating, dry throat)	—

Countries

Japan

Contacts

Public ContactTsuoyoshi Takahama

Seishukai Clinic Clinical trial office

t-takahama@seishukai.or.jp080-4410-9269

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026