The Multicenter STudy On a Precise algorithm for diagnosis of Heart Failure with Preserved Ejection Fraction (STOP-HFPEF)

The Multicenter STudy On a Precise algorithm for diagnosis of Heart Failure with Preserved Ejection Fraction (STOP-HFPEF) - STOP-HFPEF

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000054565

Enrollment

800

Registered

2024-07-01

Start date

2023-10-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart failure with preserved ejection fraction

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Participants aged 20 years and older are included if they meet the criteria outlined in the Japanese Circulation Society Acute and Chronic Heart Failure Guidelines, as well as the classification of heart failure stages defined by joint reports from the American, European, and Japanese Heart Failure Societies. Specifically, cases in stage A or B, representing risk stages of heart failure, and those diagnosed with stage C heart failure are targeted.

Exclusion criteria

Exclusion criteria: Exclusion criteria are as follows: (1) patients unable or unwilling to provide written consent, (2) patients for whom appropriate echocardiographic images for image analysis cannot be obtained, (3) patients with two or more heart failure hospitalizations within the past year (fitting the criteria for stage D heart failure), (4) patients post-mitral valve intervention (post-mitral valve repair, replacement, or clip placement), (5) patients with planned cardiac surgery at the time of enrollment, (6) patients with severe aortic valve or mitral valve disease, (7) patients on dialysis (including scheduled patients), and (8) cases where heart failure symptoms or clinical signs worsen and medication changes are made between patient enrollment in the study and the conduct of exercise stress echocardiography.

Design outcomes

Primary

Measure	Time frame
To establish a novel HFpEF diagnostic algorithm	—

Secondary

Measure	Time frame
To evaluate the clinical utility of this new HFpEF diagnostic score, secondary outcomes will include comparisons of heart failure incidence rates, cardiovascular death, the number of major cardiovascular events (acute coronary syndrome, heart failure requiring hospitalization, incident atrial fibrillation), and overall mortality rates.	—

Countries

Japan

Contacts

Public ContactYu KAWADA

Nagoya City University Graduate School of Medical Sciences Department of Cardiology

yu.kawada@outlook.jp052-853-8221

Outcome results