Brain metastases
Conditions
Interventions
None listed
Sponsors
Aichi Cancer Center Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Hippocampal-avoindance whole-brain radiotherapy is planned for multiple brain metastases (2) No indication for surgery or stereotactic radiotherapy for brain metastases (3) Brain metastases are confirmed by post-gadrinium enhanced T1-weighted 1-mm slice thickness MRI images (4) Extracranial disease is controlled, and at least 5 brain metastases have been identified. (5) No brain metastasis is identified in the hippocampus or within 5 mm of the surrounding area (6) Primary disease is non-small cell lung cancer or non-triple negative breast cancer with a GPA score of 2.5 or more at the diagnosis of brain metastases (7) Written informed consent for this study has been obtained.
Exclusion criteria
Exclusion criteria: (1) Leptmeningeal dissemination has been diagnosed (2) Unable to assess cognitive function at the diagnosis of brain metastases (3) Has a history of whole-brain radiotherapy (4) Otherwise deemed by the physician in charge as not appropriate for registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intracanial progression-free survival, cognitive function at 1-year and 2-year, change in employment status at 1-year and 2-year | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival, intracranial recurrence, hippocampal recurrence, change in cognitive function every 3 months, change in employment status every 3 months, QOL, adverse events, salvage treatment | — |
Countries
Japan
Contacts
Public ContactYutaro Koide
Aichi Cancer Center Hospital Department of Radiation Oncology
Outcome results
None listed