External Validation of HACOR Score and Updated HACOR Score in Type 1 Acute Respiratory Failure Patients Undergoing High Flow Nasal Therapy (HFNT) and Development of a New Predictive Model

External Validation of HACOR Score and Updated HACOR Score in Type 1 Acute Respiratory Failure Patients Undergoing High Flow Nasal Therapy (HFNT) and Development of a New Predictive Model - External Validation of HACOR Score and Updated HACOR Score in Type 1 Acute Respiratory Failure Patients Undergoing High Flow Nasal Therapy (HFNT) and Development of a New Predictive Model

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000054374

Enrollment

300

Registered

2024-09-01

Start date

2024-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Based on the provided text, here is the English translation of the inclusion and exclusion criteria: Inclusion Criteria: Patients aged 18 years or older with acute type 1 respiratory failure using HFNT Exclusion Criteria: Subjects who meet any of the following criteria will not be included in this study. Patients with respiratory failure due to trauma (patients with trauma registered as the main diagnosis) Patients diagnosed with COVID-19 at the time of hospital admission Patients usi

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Patients aged 18 years or older with acute type 1 respiratory failure using HFNT Acute type 1 respiratory failure is defined as a condition that meets any of the following criteria: arterial oxygen tension (PaO2) of 60 Torr or less, or arterial oxygen saturation (SaO2) of 90% or less under room air inhalation. Alternatively, if a respiratory disorder is present and arterial blood gases cannot be measured under room air inhalation, central cyanosis is observed.

Exclusion criteria

Exclusion criteria: Exclusion Criteria: Subjects who meet any of the following criteria will not be included in this study. Patients with respiratory failure due to trauma (patients with trauma registered as the main diagnosis) Patients diagnosed with COVID-19 at the time of hospital admission Patients using HFNT after weaning from mechanical ventilation or after noninvasive positive pressure ventilation Patients with "Do Not Intubate" status at the time of HFNT initiation

Design outcomes

Primary

Measure	Time frame
Primary Endpoint: Treatment failure within 24 hours of HFNT initiation (endotracheal intubation, transition to noninvasive positive pressure ventilation, or death)	—

Secondary

Measure	Time frame
Outcome at ICU discharge 28-day mortality Outcome at hospital discharge Length of hospital stay Length of ICU stay Endotracheal intubation within 48 hours Endotracheal intubation during the observation period	—

Countries

Japan

Contacts

Public ContactHiromu Okano

St. Luke's International Hospital Department of Critical Care Medicine

okano.hiromu.a5@luke.ac.jp0335445151

Outcome results