Effects of natural honey intake on glucose metabolism in type 2 diabetes mellitus

Effects of natural honey intake as a substitute eating between meals on glucose metabolism in type 2 diabetes mellitus - NAOMI Study (Effects of NAtural hOney intake as a substitute eating between meals on glucose MetabolIsm in type 2 diabetes mellitus)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000054239

Enrollment

Registered

2024-04-30

Start date

2024-05-13

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes Mellitus

Interventions

Duration of intervention 1) Intake of snacks mainly consisting of carbohydrates (4 weeks) 2) Consumption of natural honey as a substitute for snacks (4 weeks) Amount and number of interventions The

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: bbb

Exclusion criteria

Exclusion criteria: bbb

Design outcomes

Primary

Measure	Time frame
Non-inferiority of the change in glycoalbumin (GA) during the natural honey substitute intake period against the change in GA during the regular snack intake period.	—

Secondary

Measure	Time frame
1) Non-inferiority in the change in HbA1c during the natural honey substitute intake period compared to the change in HbA1c during the regular snack intake period. 2) Regarding the following factors, perform statistical analysis on changes in the regular snack consumption period and the natural honey substitute consumption period. (Weight, BMI, hemogram, blood cell counts (white blood cell differential), Total cholesterol (TC), LDL-C, HDL-C, TG, total protein, albumin, creatinine, eGFR, uric acid, AST(GOT), ALT(GPT), GGT, total bilirubin, fasting blood glucose level, fasting blood insulin, fasting blood C-peptide, HbA1c, glycoalbumin (GA), hs-CRP, AGE sensor measurements. 3) Histogram evaluation and variance analysis of the snack intake satisfaction survey results. 4) Perform other comprehensive analyzes as necessary.	—

Measure

Time frame

1) Non-inferiority in the change in HbA1c during the natural honey substitute intake period compared to the change in HbA1c during the regular snack intake period. 2) Regarding the following factors, perform statistical analysis on changes in the regular snack consumption period and the natural honey substitute consumption period. (Weight, BMI, hemogram, blood cell counts (white blood cell differential), Total cholesterol (TC), LDL-C, HDL-C, TG, total protein, albumin, creatinine, eGFR, uric acid, AST(GOT), ALT(GPT), GGT, total bilirubin, fasting blood glucose level, fasting blood insulin, fasting blood C-peptide, HbA1c, glycoalbumin (GA), hs-CRP, AGE sensor measurements. 3) Histogram evaluation and variance analysis of the snack intake satisfaction survey results. 4) Perform other comprehensive analyzes as necessary.

—

Countries

Japan

Contacts

Public ContactTakeshi Matsumura

Faculty of Life Sciences, Kumamoto University Department of Metabolic Medicine

takeshim@gpo.kumamoto-u.ac.jp0963735169

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026