jaw deformity
Conditions
Interventions
This study does not use any special test drugs or equipment. Cefazolin sodium for injection (CEZ) used, the route of administration is intravenous injection, and the single dose is 1 g. Single intra
Sponsors
Tohoku University Graduate School of Dentistry
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The subjects were cases in which maxillary and maxillary osteotomies (2 jaw surgery) were indicated in the preoperative evaluation. In addition, subjects with no signs of inflammation or symptoms in the jawbone area before surgery were included.
Exclusion criteria
Exclusion criteria: (Exclusion to affect effectiveness evaluation) (1) Patients with diabetes or blood diseases (2) Patients with inflammatory findings in the jawbone area, risk of infective endocarditis (IE), and risk of drug-induced osteonecrosis of the jaw (MRONJ) (3) Patients taking steroids or immunosuppressive drugs (4)Patients participating in other studies (Exclusion to affect safety assessment) (4) Patients with allergies to cephem antibiotics (5) Patients who are taking anticoagulants, antithrombotic drugs, etc. and are at risk of bleeding (6)Patients with renal dysfunction (7) Women who are pregnant, may become pregnant, within 28 days after giving birth, or are breastfeeding. (Exclusion from the perspective of risk/benefit balance) (8) Patients who are judged to be difficult to participate in research due to psychosis or psychiatric symptoms
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The following items on the 1st, 3rd, 7th, 14th, and 28th days after surgery Presence or absence of fever, presence or absence of cheek swelling, painless mouth opening, pain score (NRS), presence or absence of wound swelling, presence or absence of wound drainage. | — |
Countries
Japan
Contacts
Public ContactYushi Ezoe
Tohoku University Graduate School of Dentistry Division of Oral and Maxillofacial Surgery
Outcome results
None listed