Open public recruiting
Conditions
Interventions
Low-intensity aerobic exercise group: Starting with a power bicycle, and subsequently allowing subjects to choose aerobic exercise training equipment according to their personal preferences, such as a
s one-repetition maximum for each exercise movement. Each set consists of 8 repetitions, followed by 2 sets per movement. After completing one set, there is a rest period of 2-3 minutes before proceed
Sponsors
Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Conforming to the diagnostic criteria for sarcopenia in the elderly as established by the Asian Working Group for Sarcopenia (AWGS), having signed an informed consent form, and being in a stable state of chronic disease.
Exclusion criteria
Exclusion criteria: Patients with conditions affecting muscles and bones, such as renal failure, cancer, stroke, severe liver disease, diabetes, thyroid or parathyroid disorders; on medications like glucocorticoids, sex hormones, thyroid hormones; with severe heart conditions, cognitive or psychiatric impairments, cancer, joint contractures, metal implants, or severe disabilities; had recent major surgeries or refuse to consent to the study management are excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measures of this study include muscle mass, muscle strength, 4-meter walking speed, and the longitudinal changes in mTOR and autophagy assessed at four time points. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood indicators, Timed Up and Go Test (TUGT), Short Physical Performance Battery (SPPB), 6-minute walk distance, dietary nutrition and sleep status, physical activity levels, and changes in maximal oxygen uptake. | — |
Countries
Asia(except Japan)
Contacts
Public ContactKai Zheng
Shanghai University of Medicine and Health Sciences China
Outcome results
None listed