active
Conditions
Interventions
Milrinone group (M group) will include patients who will be subjected to milrinone a loading dose of milrinone acetate 50 mic/kg over 10 minutes followed by 0.3-0.8 mic/kg/min. infusion.
Dobutamin
Sponsors
Mansoura university hospitals
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients over 18 years scheduled for on pump cardiac surgery who developed new RV systolic dysfunction after CPB separation were eligible. RV dysfunction was defined as TAPSE less than 17 mm on intraoperative echocardiography together with clinical signs requiring inotropic support persistent hypotension and elevated CVP. Enrolment occurred when the clinical team decided to initiate inotropic therapy during or immediately after CPB weaning
Exclusion criteria
Exclusion criteria: Emergency surgery Prior intake of inotropic support. Severe hepatic, renal impairment. Patients for pulmonary thromboendarterectomy, Contraindication for use of TEE
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Echocardiographic RV function indices TAPSE | — |
Secondary
| Measure | Time frame |
|---|---|
| Other echocardiographic parameters RVFAC, PASP, LVOT VTI Duration of mechanical ventilation Length of ICU stay Incidence of significant arrhythmias (new onset AF, VT) requiring intervention Incidence of profound hypotension (MAP <55 mmHg) requiring rescue therapy Need for additional inotropic or vasopressor support | — |
Countries
Africa
Contacts
Public Contactmohammed hegazy
Mansoura university hospital anesthesia and surgical intensive care department
Outcome results
None listed