Adult
Conditions
Interventions
Apply 6 mg/cm2 (37.5 mg total) of royal jelly cream to the inner forearm 2.5 cm square for 2 hours.
Sponsors
Yamada Bee Company, Inc.
Research Center for Immunological Analysis, Inc.
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1) Japanese females aged 40-60 years. 2) Subjects can understand and comply with the rules written in protocol during clinical study period. 3) Subjects whose written informed consent has been obtained.
Exclusion criteria
Exclusion criteria: 1) Subjects using cosmetics containing royal jelly. 2) Subjects diagnosed with atopic dermatitis and skin hypersensitivity. 3) Subjects attending or planning to attend dermatology clinics (for treatment of atopic dermatitis, etc.). 4) Pregnant or lactating women. 5) Subjects undergoing hospitalization and medication for the treatment of disease. 6) Subjects who have factors or symptoms on the skin of the inner forearm which may affect the test results or who have received cosmetic medical treatment. 7) Subjects receiving hormone replacement therapy (estrogen, progesterone preparations (oral, paste, ointment, etc.)). 8) Subjects who cannot avoid sunburn during the test period. 9) Subjects who work or exercise outdoors for long time. 10) Subjects who cannot be prohibited from receiving beauty care (facial esthetics, epilation, etc.). 11) Subjects participating in another clinical trial. 12) Subjects who have seasonal allergic symptoms such as hay fever and are taking medication during the test period. 13) Subjects taking bee products such as royal jelly and propolis. 14) Subjects who are judged as unsuitable for this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The amount of skin penetration of the RJ components (Tape stripping) | — |
Secondary
| Measure | Time frame |
|---|---|
| Water content of stratum corneum Transepidermal water loss pH Sebum Skin texture | — |
Countries
Japan
Contacts
Public ContactYuki Haruna
Yamada Bee Company, Inc. Functional Ingredient research section, Institute for Bee Products & Health Science, R&D department
Outcome results
None listed