Alzheimer'
Conditions
Interventions
Sponsors
Kurita hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1, Meet the diagnostic criteria for Alzheimer's disease and insomnia of DSM-5. 2, MMSE score is 21 or higher. 3, The patient dose not use benzodiazepines, antipsychotics, antidepressants, antiepileptics, antiparkinsonian drugs, antihistamines, or orexin receptor antagonists.
Exclusion criteria
Exclusion criteria: 1, Comorbid dementia other than Alzheimer's disease. 2, Comorbid schizophrenia, mood disorder, anxiety disorder, drug/substance addiction, or personality disorder. 3, Serious physical illnesses such as cerebrovascular disease, cardiac disease, renal dysfunction, and neurological disease. 4, The patient has a coexisting sleep-related breathing disorder (respiratory event index of 10 or more on the apnomonitor). 5, The principal investigator or attending physician determines that the subject is unsuitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of REM sleep duration and amyloid-beta 42/40 ratio before and after administration of suvorexant | — |
Countries
Japan
Contacts
Public ContactAkira Tanaka
Kurita hospital psychiatry
Outcome results
None listed