Quantification of radiation pneumonitis and Prediction of Respiratory Function Changes Using 4D-CT and Respiratory Function Testing

Quantification of radiation pneumonitis and Prediction of Respiratory Function Changes Using 4D-CT and Respiratory Function Testing - Quantification of radiation pneumonitis and Prediction of Respiratory Function Changes Using 4D-CT and Respiratory Function Testing

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000054062

Enrollment

100

Registered

2024-04-04

Start date

2023-08-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

malignant thoracic tumor

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients must be at least 20 years of age and have histologically proven malignancy. 2) Patients with no previous radiation therapy to the chest. 3) Patients who are scheduled to undergo radical radiotherapy for lung cancer with a total dose of 40 Gy or more.

Exclusion criteria

Exclusion criteria: 1) Patients with active interstitial pneumonia requiring treatment. 2) Patients with serious complications (liver cirrhosis, diabetes, cardiac disease, etc.). 3) Pregnant and lactating women.

Design outcomes

Primary

Measure	Time frame
1) Quantification of radiation pneumonitis 2) Prediction of post-treatment respiratory function changes in radiotherapy patients	—

Secondary

Measure	Time frame
1) Prediction of radiation pneumonitis range 2) Correlation between pulmonary function images obtained from 4D-CT images and respiratory function tests 3) Influence of drugs used in combination with radiotherapy on respiratory function	—

Countries

Japan

Contacts

Public ContactTomohiro Itonaga

Tokyo Medical University Department of Radiology

itonaga@tokyo-med.ac.jp03-3342-6111

Outcome results