Asthma and Clinical Cough-Variant Asthma
Conditions
Interventions
Measure airway resistance using MostGraph in patients diagnosed with asthma or cough variant asthma, in conjunction with diagnostic tests.
Sponsors
Nippon Medical School
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: From November 2020 to March 2024, patients diagnosed with clinical cough-variant asthma and asthma at the Japan Medical University Hospital Respiratory Medicine Department and Japan Medical University Respiratory Care Clinic were prospectively enrolled and their data analyzed. This study was devised and executed to investigate the results obtained when performing Impulse Oscillometry (IOS) using the MostGraph in asthma patients, compare these results with those of patients with cough-variant asthma, and assess whether the MostGraph results reflect the airway lesions of asthma patients. The aim was to examine the potential usefulness of the MostGraph in understanding the airway lesions of asthma patients. The selection criteria were as follows: 1 Patients aged 20 years or older (both sexes). 2 Patients diagnosed with asthma or CVA at our facility or those referred from other institutions with a diagnosis of asthma based on reversible airflow tests and clinical history, where exclusion of other diseases was confirmed. 3 Patients with stable symptoms persisting for at least three months, continuing until the completion of the assessments, and not requiring the introduction of new treatments until the initiation of treatment for the disease diagnosed after these assessments. 4 Patients without any severe condition requiring immediate treatment. 5 Patients in whom any disease associated with airflow obstruction requiring medications other than bronchodilators could be ruled out, and who were not taking ACE inhibitors. 6 Patients without diseases that could obscure the diagnosis of asthma or CVA. 7 Patients who have been informed about the study using an informed consent document and have provided consent to participate in this study. Note: CVA typically stands for cough-variant asthma.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1) Patients who have no symptoms, including cough or symptoms derived from asthma. 2) Patients with acute symptoms requiring immediate treatment intervention. 3) Patients with diseases causing cough requiring medication other than bronchodilators, unrelated to asthma or CVA. 4) Patients receiving medication (such as ACE inhibitors) that hinder the definitive diagnosis of asthma or CVA. 5) Patients with conditions that hinder the definitive diagnosis of asthma or CVA. 6) Patients lacking decision-making capacity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A comparison of Impedance Oscillation system utilizing MOST graph at the time of diagnosis between asthma patients enrolled since ethical approval from November 2020 at our facility and patients diagnosed with clinical cough-variant asthma | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare various examination results and Impulse Oscillometry (IOS) results using MOST graph between asthma patients enrolled since ethical approval from November 2020 at our facility and patients diagnosed with cough-variant asthma, which is considered a prodromal state of asthma with potential transition to asthma. | — |
Countries
Japan
Contacts
Public ContactYosuke Tanaka
Nippon Medical School Department of Respiratory Medicine
Outcome results
None listed