Bone Morphogenetic Protein-2 Levels in GFF after Hydroxyapatite Tricalcium Phosphate Bone Graft in Vertical Defect, A RCT

Bone Morphogenetic Protein-2 Levels in Gingival Crevicular Fluid Following Hydroxyapatite Tricalcium Phosphat Bone Graft in Vertical Defect, A Randomized Controlled Trial - Bone Morphogenetic Protein-2 Levels in Gingival Crevicular Fluid Following Hydroxyapatite Tricalcium Phosphat Bone Graft in Vertical Defect, A Randomized Controlled Trial:Bone Morphogenetic Protein-2 Levels in Gingival Crevicular Fluid Following Hydroxyapatite Tricalcium Phosphat Bone Graft in Vertical Defect, A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000053980

Enrollment

Registered

2024-03-31

Start date

2022-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis patient with vertical bone defect and systemically healthy

Interventions

Periodontal regenerative surgery in vertical bone defect, the test group received HA-TCP bone graft and membrane The control group only received membrane

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria included male or female patients aged of 30 years, having periodontal pocket 6 mm clinically examined using a UNC 15 probe with vertical defects confirmed by radiograph, no inadequate restorations and carious lesions, non-smokers and had gone through the initial phase with a plaque score of 10%.

Exclusion criteria

Exclusion criteria: Exclusion patients included patients diagnosed with aggressive periodontitis, pregnant and lactating women, wearing orthodontic appliances, taking antibiotics, anti-inflammatory and immunosuppressants for the last three months, and having a history of uncontrolled systemic disease

Design outcomes

Primary

Measure	Time frame
Increase of BMP-2 levels in GCF	—

Secondary

Measure	Time frame
Reduction of periodontal pocket	—

Countries

Asia(except Japan)

Contacts

Public ContactIra Komara

Dental Faculty Universitas Padjadjaran Indonesia Periodontology

ira.komara@unpad.ac.id+62222504985

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026