Comparative effects of dual-task training versus combined exercise training in water and on land on cognition, balance, and gait of patients with multiple sclerosis: A Study protocol of a randomized factorial trial

Comparative effects of dual-task training versus combined exercise training in water and on land on patients with multiple sclerosis: A Study protocol of a randomized factorial trial - the effects of dual-task training versus combined exercise training in water and on land on patients with multiple sclerosis.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000053947

Enrollment

190

Registered

2024-03-22

Start date

2024-04-06

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

exercise therapy pre-post intervention of patients with multiple sclerosis

Interventions

Intervention group: dual-task training in water. Intervention group: dual task training on land. Intervention group: combined exercise training in water. Intervention group: combined exercise training

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with relapsing-remitting MS as outlined by the McDonald criteria, The EDSS between 1.0 and 5.5, Relapse-free for the last 3 months, lack of regular physical exercise,(no training within the last three months), willingness to participate in the current study, Cognitive impairments that will be characterized by scores below the standard criterion at least 1.5 standard deviations from the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS).

Exclusion criteria

Exclusion criteria: Unable to comply with the requirements of the protocol Inability to stand and walk without aids and braces Changes in medication in past 2 months, History of cardiovascular, kidney, or other chronic diseases, Pregnancy in past 12 months, medical conditions interfering with mobility, MS-like syndromes such as neuromyelitis optica, or major problems with hearing, vision, and perception.

Design outcomes

Primary

Measure	Time frame
The Symbol Digit Modalities Test (SDMT) in The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS).	—

Secondary

Measure	Time frame
The California Verbal Learning Test (CVLT) and The Brief Visuospatial Memory Test (BVMTR) in The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). kinetics and kinematics throughout the balance and gait cycle, encompassing spatiotemporal parameters, sagittal plane angles, and moments of the hip, knee, and ankle, as well as anteroposterior, mediolateral, and vertical ground reaction forces.	—

Measure

Time frame

The California Verbal Learning Test (CVLT) and The Brief Visuospatial Memory Test (BVMTR) in The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). kinetics and kinematics throughout the balance and gait cycle, encompassing spatiotemporal parameters, sagittal plane angles, and moments of the hip, knee, and ankle, as well as anteroposterior, mediolateral, and vertical ground reaction forces.

—

Countries

Asia(except Japan)

Contacts

Public Contactsahar nazary soltan ahmad

kharazmi university sport medicine

saharnazary1992@gmail.com+989106740486

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026