Healthy volunteers
Conditions
Interventions
None listed
Sponsors
Tohoku University
The University of Tokyo Tenshi College Tokyo Medical University LSI Sapporo Clinic Bukkyo University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: <FDG-PET/CT> 1. Healthy adult volunteers 2. Aged 18 and over 3. Male and female 4. Individuals who have given written consent to participate in the study. Individuals who have undergone FDG-PET/CT examinations in past studies and, who have difficulty obtaining written consent for the use of existing samples/information, and who have not refused the use of these materials. <NIR-TRS> 1. Healthy adult volunteers 2. Aged 18 and over 3. Male and female 4. Individuals who have given written consent to participate in the study. Individuals who have undergone NIR-TRS examinations in past studies, who have difficulty obtaining written consent for the use of existing samples/information, and who have not refused the use of these materials. <Epigenome> 1. Volunteers who underwent FDG-PET/CT 2. Aged 18 and over 3. Male 4. Volunteers with high, moderate, and low brown fat activity. 5. Individuals who have given written consent to participate in the study Individuals who have undergone FDG-PET/CT examinations in past studies, who have difficulty obtaining written consent for the use of existing samples/information, and who have not refused the use of these materials. <DLW> 1. Healthy volunteers 2. Aged 3 and 6 3. Male and female 4. The guardians of participants who have not refused the use of data that was obtained in the past studies
Exclusion criteria
Exclusion criteria: <FDG-PET/CT> 1. Individuals with dysfunction of liver, renal, cardiovascular, respiratory, endocrine and nervous systems, or with metabolic disorders, diabetes, consciousness disorders or other disease. 2. Individuals who regularly take medications for diabetes, hyperlipidemia or hypertension. 3. Individuals who smoke over 21 cigarettes a day or consume alcohol more than 30g a day on average. 4. Individuals who are pregnant or breastfeeding 5. Individuals who are considered unsuitable for the study by investigators or medical doctor due to other reasons. <NIR-TRS> 1. Individuals with glucose intolerance, hyperlipidemia, hypertension, hyperuricemia/gout, coronary artery disease, cerebral infarction, non-alcoholic fatty liver disease, menstrual disorder, sleep apnea syndrome, motor system disease, obesity-related kidney disease or cardiovascular risk. 2. Individuals with BMI 30 kg/m^2 or more. 3. Individuals with visceral fat area over 100cm^2. 4. Individuals who are considered unsuitable for the study by investigators or medical doctor due to other reasons. <Epigenome> 1. Individuals with dysfunction of liver, renal, cardiovascular, respiratory, endocrine and nervous systems, or with metabolic disorders, diabetes, consciousness disorders or other disease. 2. Individuals who regularly take medications for diabetes, hyperlipidemia or hypertension. 3. Individuals who smoke over 21 cigarettes a day or consume alcohol more than 30g a day on average. 4. Female. 5. Individuals who are considered unsuitable for the study by the investigators due to other reasons. <DLW> N/A
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brown adipose tissue activity assessed by FDG-PET/CT, indoor/outdoor temperature assessed by iButton, brown adipose tissue density by NIR-TRS, and total energy expenditure assessed by DLW | — |
Secondary
| Measure | Time frame |
|---|---|
| Body composition, waist circumference, abdominal fat area, blood parameters including hormones and metabolites, brown fat mass, energy expenditure, respiratory quotient, diet history and nutritional intake, heart rate, blood pressure, adiposity at early lifestages, and epigenetic information in a certain type of cells, step counts, physical activity levels, and water turnover | — |
Countries
Japan
Contacts
Public ContactTakeshi Yoneshiro
Tohoku University Division of Molecular Physiology and Metabolism, Graduate School of Medicine
Outcome results
None listed