Healthy subjects
Conditions
Interventions
Shiitake
None
Sponsors
University of Tsukuba, Institute of Medicine
E-sport Co., Ltd Ohsyo Shiitake Co., Ltd National agriculture and food research organization, food research institute
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Men and women between the ages of 18 and 64 years old at the time of consent. 2. Subjects who have had common cold-like symptoms with one or more episodes of fever at least one year prior to obtaining consent. 3. Subjects who have been properly informed about the participation in this study, and who have given written consent of their own free will with full understanding.
Exclusion criteria
Exclusion criteria: 1.Subjects who are currently undergoing hospitalization or drug treatment for any disease. 2. Subjects with a history of shiitake mushroom dermatitis. 3. Subjects who cannot consume dried shiitake mushrooms due to taste. 4. Subjects who have a serious systemic disease. 5. Subjects with a history of autoimmune diseases. 6. Subjects who are currently using over-the-counter drugs, quasi-drugs, food for specified health uses, functional foods, supplements, etc. on a regular basis. 7. Subjects who work in shifts. 8. Subjects whose lifestyle (diet, sleep, exercise, etc.) is likely to change significantly during the research period. 9. Pregnant women or those of reproductive potential who are unable to use contraception during the research period. 10. Subjects with food allergies 11. Other subjects deemed inappropriate by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HLA-DR, CD40, CD86 expression levels of conventional DC (cDC), plasmacytoid DC (pDC) and monocytes (Multi-color flow cytometry analysis) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Physical condition (common cold-like symptoms) 2. body temperature 3. Mood profile (POMS2 short version) 4. Salivary IgA 5. NK cell activity 6. Adverse events 7. Multicolor flow cytometry analysis of immune cells in peripheral blood | — |
Countries
Japan
Contacts
Public ContactKoichi Hashimoto
University of Tsukuba, Institute of Medicine Clinical and translational research methodology
Outcome results
None listed