Relationship between the severity of periodontitis and changes in gut microbiota

Research on the severity of periodontitis and changes in gut mibrobiota - Research on periodontal disease and changes in gut microbiota

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000053776

Enrollment

Registered

2024-03-05

Start date

2024-04-09

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Periodontal examinations include 1) probing depth (PD), 2) clinical attachment level (CAL), 3) Degree of tooth mobility, 4) Bleeding on probing (BOP), 5) Gingival Index (GI), 6) Plaque Index (PlI), 7) plaque control record (PCR%), 8) Periodontal epithelial surface area (PESA), 9) Periodontal inflammed surface area (PISA), and 10) based on the results of X-ray examination. Patients diagnosed with slight or sever periodontitis.

Exclusion criteria

Exclusion criteria: Patients who have not taken any antibiotics within the last 3 months of registration date. Smoker.

Design outcomes

Primary

Measure	Time frame
Based on the results of the periodontal examination and radiographic examination, patients will be divided into two groups: slight and severe periodontitis, and those who enter an agreement with the analysis will receive a research stool collection kit and questionnaire. Patient will collect a stool sample at home, fill out the medical questionnaire, and mail it to Symbiosis Solutions, Inc. The results of gut microbiota analysis will be provided to the patient, and the results of periodontal examination with ID code will be sent to Symbiosis Solutions, Inc. We will compare and analyze the results of periodontal examinations and gut microbiota. The target number of patients is expected to be 60 (30 patients with slight and 30 patients with severe periodontitis), and statistical analysis will be conducted to compare the severity of periodontitis, clinical parameter of periodontal examinations and gut micorbiota in both groups.	—

Measure

Time frame

Based on the results of the periodontal examination and radiographic examination, patients will be divided into two groups: slight and severe periodontitis, and those who enter an agreement with the analysis will receive a research stool collection kit and questionnaire. Patient will collect a stool sample at home, fill out the medical questionnaire, and mail it to Symbiosis Solutions, Inc. The results of gut microbiota analysis will be provided to the patient, and the results of periodontal examination with ID code will be sent to Symbiosis Solutions, Inc. We will compare and analyze the results of periodontal examinations and gut microbiota. The target number of patients is expected to be 60 (30 patients with slight and 30 patients with severe periodontitis), and statistical analysis will be conducted to compare the severity of periodontitis, clinical parameter of periodontal examinations and gut micorbiota in both groups.

—

Countries

Japan

Contacts

Public ContactMasaki Tanatsu

Nihon University School of Dentistry at Matsudo Research Administration Division

tamatsu.masaki@nihon-u.ac.jp047-360-9273

Outcome results