Japanese Prospective Cohort Evaluating Features of Patients with UncontRolled Asthma Achieving Clinical REmission

Japanese Prospective Cohort Evaluating Features of Patients with UncontRolled Asthma Achieving Clinical REmission - J-CIRCLE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000053771

Enrollment

300

Registered

2024-04-01

Start date

2024-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

asthma

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with uncontrolled asthma who will start a new biologic at age 20-90 years old

Exclusion criteria

Exclusion criteria: Patients who are considered inappropriate for enrollment.

Design outcomes

Primary

Measure	Time frame
To evaluate whether clinical remission after 1-year treatement with biologics could reflect long-term clinical remission after 3-year treatment	—

Secondary

Measure	Time frame
To evaluate whether longitudinal changes in chest CT findings from baseline to 1-year after treatment could reflect long-term clinical remission. To evaluate relapse rate during 3-year follow-up in patients who achieve 1-year clinical remission, and then discontinue biologics. To evaluate whether clinical remission after 1-year biologics treatment could be associated with improvement of CT findings after 3-year treatment. To evaluate whether baseline clinical factors and CT findings could predict 1-year and 3-year clinical remissions.	—

Measure

Time frame

To evaluate whether longitudinal changes in chest CT findings from baseline to 1-year after treatment could reflect long-term clinical remission. To evaluate relapse rate during 3-year follow-up in patients who achieve 1-year clinical remission, and then discontinue biologics. To evaluate whether clinical remission after 1-year biologics treatment could be associated with improvement of CT findings after 3-year treatment. To evaluate whether baseline clinical factors and CT findings could predict 1-year and 3-year clinical remissions.

—

Countries

Japan

Contacts

Public ContactNAOYA TANABE

Kyoto University Department of Respiratory Medicine

ntana@kuhp.kyoto-u.ac.jp+81-75-751-3830

Outcome results