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A Meta-Analysis of Off-Label Low Dose Versus Recommended Standard Dose of Direct Oral Anticoagulants in the Japanese Non-valvular Atrial Fibrillation Patients

A Meta-Analysis of Off-Label Low Dose Versus Recommended Standard Dose of Direct Oral Anticoagulants in the Japanese Non-valvular Atrial Fibrillation Patients - A Meta-Analysis of Off-Label Low Dose Versus Recommended Standard Dose of Direct Oral Anticoagulants in the Japanese Non-valvular Atrial Fibrillation Patients

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000053756
Enrollment
Unknown
Registered
2024-06-20
Start date
2024-03-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-valvular atrial fibrillation

Interventions

None listed

Sponsors

National Hospital Organization
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Registry studies that included patients with non-valvular atrial fibrillation who were administered DOACs. 2. Studies reporting the incidence of major bleeding and stroke/systemic embolism in patient groups administered with recommended and off-label low doses of DOACs. 3. Studies conducted in Japan.

Exclusion criteria

Exclusion criteria: Studies that do not report the incidence of either major bleeding or stroke/systemic embolism in patient groups administered with recommended doses and off-label low doses of DOACs.

Design outcomes

Primary

MeasureTime frame
1. Stroke or systemic embolism. 2. Major bleeding—

Secondary

MeasureTime frame
Non-major clinically relevant bleeding—

Countries

Japan

Contacts

Public ContactAkinori Sairaku

National Hospital Organization Higashihiroshima Medical Center Cardiology

rjrgw059@ybb.ne.jp0824232176

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026