healthy volunteers
Conditions
Interventions
Oral administration of pregabalin 150 mg, mirogabalin 15 mg, duloxetine 60 mg, amitriptyline 75 mg, vaccinia virus-inoculated rabbit inflamed skin extract 8 units, or lactose hydrate 2 tablets (contro
Sponsors
Division of Dental Anesthesiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: after informed consent is obtained, over 18 years old, healthy volunteers
Exclusion criteria
Exclusion criteria: the inability to give informed consent, under 18 years old, patients with a history of hypersensitivity to any of these ingredients, which is a contraindication to the administration of drugs of pregabalin, myrogabalin, duloxetine, amitriptyline, or vaccinia virus inoculated rabbit inflammatory skin extract, patients on monoamine oxidase (MAO) inhibitors or within 2 weeks of discontinuation of MAO inhibitors, patients with severe hepatic dysfunction, angle-closure glaucoma, early recovery from myocardial infarction, or urinary retention (prostate disease, etc.), requiring caution in administration, acute intoxication with alcohol, sleeping pills, analgesics, opioid analgesics or psychotropic drugs, within 1 week after receiving or discontinuing nalmefene hydrochloride hydrate, epilepsy not adequately controlled by treatment, renal dysfunction, severe congestive heart failure, elderly patients, history of angioedema, tendency or history of drug dependence, psychiatric disorders, pregnant women, and nursing mothers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The evaluation of CPM effect before and after oral medication of the drugs for neuropathic pain. CPM effect is evaluated by pressure pain threshold (PPT) before and during conditioning stimulus. | — |
Secondary
| Measure | Time frame |
|---|---|
| the modulation of QST (the Thermal Pain Illusion(TPI), Temporal Summation(TS), Offset Analgesia(OA) etc) and the effect of background (for example, psychology test including SDS, STAI, PCS etc), and the stress evaluated by catecholamine concentrations in plasma, urine and sweat. | — |
Countries
Japan
Contacts
Public ContactYuka Oono
Department of Diagnostic and Therapeutic Sciences, School of Dentistry, Meikai University Division of Dental Anesthesiology
Outcome results
None listed