Development of a biocompatible sedation method based on oxytocin in the brain

Development of a biocompatible sedation method based on oxytocin in the brain - Brain oxytocin sedation

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000053683

Enrollment

Registered

2024-03-01

Start date

2024-03-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oral diseases

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Patients undergoing dental treatment under intravenous sedation or laughing gas inhalation sedation at the Department of Comprehensive Special Dentistry of Nagasaki University Hospital or Nagasaki Prefectural Oral Health Center (2) Patients over 18 years old (3) Patients who have obtained consent from the patient or a surrogate (when it is deemed difficult to provide appropriate IC to the patient).

Exclusion criteria

Exclusion criteria: (1) Patients for whom saliva sampling is not possible before sedation (2) Patients for whom it is difficult to attach EEG electrodes (3) Other cases in which the Principal Investigator and the Principal Investigator deem the subject to be inappropriate as a research subject will be excluded from the study.

Design outcomes

Primary

Measure	Time frame
1) Oxytocin concentration in saliva 2) Rate of change in parasympathetic nervous system frequency 3) Rate of change in the rate of appearance of alpha waves in the frontal EEG	—

Countries

Japan

Contacts

Public ContactTerumi Ayuse

Nagasaki University Hospital Special Care Dentistory

ttagawa@nagasaki-u.ac.jp0958197717

Outcome results