sepsis
Conditions
Interventions
Intervention: dynamic IVC variation-guided fluid resuscitation 1. Patients were categorized into mechanical ventilation (MV) and spontaneous breathing (SB) subgroups. 2. MV patients were measured b
18% and >
=18% being treated as fluid non-responsiveness, and fluid responsiveness, respectively. SB patients were measured by ultrasound for IVC collapsibility index with a value of <
50% and >
=50% being treated as fluid non-responsiveness and fluid responsiveness, respectively. 3.Crystalloid (mostly 0.9%NaCl solution) 500 milliliters (mL) in 15 minutes (min) was administered intravenousl
65 mmHg) received intravenous vasopressor. 5. All patients received standard treatment with intensive monitoring for 6 hours, and were tracked until shock resolution and discharge, transfer or death
8 and >
=8 mmHg being treated as responsiveness and non-responsiveness, respectively. 2. Fluid responsive patients received crystalloid (mostly 0.9%NaCl solution) intravenously 500 mL in 15 min and CVP meas
65 mmHg) received intravenous vasopressor. 4. All patients received standard treatment with intensive monitoring for 6 hours, and were tracked until shock resolution and discharge, tr
Sponsors
Thammasat University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) age of >=18 years 2) suspected infection 3) SOFA score of >=2 4) systolic blood pressure (SBP) <90mmHg or SBP decrease > 40 mmHg from the original level or mean arterial pressure (MAP) <70 mmHg 5) requirement of intravenous fluid to maintain stable hemodynamics
Exclusion criteria
Exclusion criteria: 1) pregnancy 2) pulmonary edema due to cardiovascular diseases 3) inability to be in a supine position, e.g., spine deformities 4) difficult or inaccurate US measurement of IVC diameter, e.g., IVC compression from any causes 5) limitation of central venous catheterization e.g., structural abnormalities of internal jugular vein or superior vena cava
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in the SOFA score from the diagnosis of sepsis to 72 hours later | — |
Secondary
| Measure | Time frame |
|---|---|
| SOFA score at 72 hours after the diagnosis of sepsis, change in the SOFA score from the diagnosis of sepsis to 7 days later, proportion of patients receiving vasopressor, duration of vasopressor, and incidence of pulmonary edema in 7 days after the diagnosis of sepsis | — |
Countries
Asia(except Japan)
Contacts
Public ContactThiti Sricharoenchai
Thammasat University Division of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine
Outcome results
None listed