Genotoxicity with the use of fixed orthodontic appliances and folic acid

Evaluation of genomic instability and genotoxicity with the use of fixed orthodontic appliances and folic acid intake - Evaluation of genomic instability and genotoxicity with the use of fixed orthodontic appliances and folic acid intake

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000053676

Enrollment

Registered

2024-02-21

Start date

2023-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy teenagers and adults

Interventions

Group III: Orthodontic fixed appliances and folic acid intake Administration: 400 mcg DFE (dietary folate equivalents)/day/three months Group I: Control No intervention Group I: Orthodontic fixed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who meet the criteria of: 1. Need of orthodontic treatment 2. Non-smoking 3. No oral or systemic diseases 4. Without metal restorations or oral prostheses 5. Clinically healthy oral mucosa 6. No prior orthodontic treatment 7. No occupational exposure to metals 8. Not receiving medications or supplements 9. No known allergies to jewelry, watches or sources of nickel and chromium

Exclusion criteria

Exclusion criteria: 1. Pregnant women 2. Patients with cancer or taking antineoplastics

Design outcomes

Primary

Measure	Time frame
Frequency of micronuclei and nuclear abnormalities in patients with orthodontic fixed appliances and folic acid intake	—

Secondary

Measure	Time frame
Frequency of micronuclei and nuclear abnormalities in three groups: control, patients with orthodontic fixed appliances, and patients with orthodontic fixed appliances and folic acid intake in a six-month period	—

Countries

North America

Contacts

Public ContactDavid Bautista Martinez

Autonomous University State of Mexico (UAEMex) Orthodontics department

dr.david.bautista@gmail.com+527222179070

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026