Detection of Brain Oxygen Supply Issues with New MRI Technology

Noninvasive diagnosis of oxygen metabolism using CEST-MRI - CEST-MRI and oxygen metabolism

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000053651

Enrollment

Registered

2024-04-01

Start date

2024-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Moyamoya disease, healthy volunteers

Interventions

None listed

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: <For Moyamoya Disease Patients> This study targets patients who meet all of the following criteria: 1. Age 16 to under 65 on the day of consent to participate in this study 2. Neuro-radiologically confirmed bilateral or unilateral Willis' circle occlusion (Moyamoya disease) 3. No neurological findings (such as aphasia, agnosia, etc.) that significantly affect neuropsychological testing 4. Mostly independent in daily life (modified Rankin scale 0-3) 5. Scheduled to undergo necessary brain oxygen metabolism evaluation test (15O-gas PET) for medical treatment 6. Consent to participate in the study has been obtained through sufficient informed consent <For Healthy Research Participants> The study targets those who meet all of the following criteria and have obtained consent to participate in the study: 1. Patients aged 18 to under 65 on the day of consent to participate in this study 2. Independent in daily life (modified Rankin scale 0-1) 3. No neurological findings (such as aphasia, agnosia, etc.) that affect neuropsychological testing 4. No history of neurological diseases (including moderate to severe head injuries) 5. Consent to participate in the study has been obtained through sufficient informed consent

Exclusion criteria

Exclusion criteria: Patients with Moyamoya syndrome Patients who may suffer health damage or mental distress due to metal in the body or claustrophobia during MRI Patients and healthy research subjects who have brain organic diseases other than Moyamoya disease that may affect the analysis results Patients with severe systemic diseases (terminal cancer, renal failure, cirrhosis, etc.) Other patients and healthy research subjects were deemed ineligible by the study physician

Design outcomes

Primary

Measure	Time frame
Comparison of CEST-MRI and Brain Oxygen Metabolism Evaluation Test (15O-gas PET) Comparison of CEST-MRI in patients and healthy participants Comparison of CEST-MRI in patients before and after surgery	—

Countries

Japan

Contacts

Public ContactShoko Hara

Institute of Science Tokyo Department of Neurosurgery

shara.nsrg@tmd.ac.jp0358035266

Outcome results