The prevalence and clinical prognosis of myocardial infarction with non-obstructive coronary arteries: a prospective multicenter observational study (REVEIL-MINOCA study)

The prevalence and clinical prognosis of myocardial infarction with non-obstructive coronary arteries: a prospective multicenter observational study (REVEIL-MINOCA study) - REVEIL-MINOCA study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000053628

Enrollment

5000

Registered

2024-02-16

Start date

2024-02-16

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute coronary syndrome

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients diagnosed with ACS who visited or were admitted hospitals in this study between study initiation and March 2028 and who meet the following eligibility criteria and do not meet any of the exclusion criteria. Eligibility criteria Patients undergoing emergency coronary angiography for the diagnosis of acute coronary syndrome, including unstable angina, ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction Patients who are 18 years of age or older Patients who can be followed up regularly once a year

Exclusion criteria

Exclusion criteria: Exclusion criteria Patients who declared non-participation in the study Patients who are regarded as inappropriate to participate in the study by the investigators

Design outcomes

Primary

Measure	Time frame
Incidence of major cardiovascular events in MINOCA and non-MINOCA cases at 1 year follow-up MACCE, major adverse cardiovascular and cerebrovascular event. composite endpoint of all-cause mortality, myocardial infarction, revascularization, stroke, systemic embolism, heart failure readmission	—

Secondary

Measure	Time frame
Secondary endpoints Rate of MINOCA cases to all enrolled ACS cases Breakdown by onset mechanism in MINOCA cases The incidence of MACCE events over time in MINOCA and non-MINOCA cases MACCE, major adverse cardiovascular and cerebrovascular event.composite endpoint of all-cause death, myocardial infarction, revascularization, stroke, systemic embolism, heart failure readmission Incidence of MACCE items over time in MINOCA and non-MINOCA cases Incidence of the following clinical outcomes over time in MINOCA and non-MINOCA cases Death Myocardial infarction Stent thrombosis Revascularization Emergency revascularization Bleeding events Stroke Systemic embolism Ischemic cardiomyopathy Hospitalization for heart failure Other all endpoints defined in ARC-25	—

Measure

Time frame

Secondary endpoints Rate of MINOCA cases to all enrolled ACS cases Breakdown by onset mechanism in MINOCA cases The incidence of MACCE events over time in MINOCA and non-MINOCA cases MACCE, major adverse cardiovascular and cerebrovascular event.composite endpoint of all-cause death, myocardial infarction, revascularization, stroke, systemic embolism, heart failure readmission Incidence of MACCE items over time in MINOCA and non-MINOCA cases Incidence of the following clinical outcomes over time in MINOCA and non-MINOCA cases Death Myocardial infarction Stent thrombosis Revascularization Emergency revascularization Bleeding events Stroke Systemic embolism Ischemic cardiomyopathy Hospitalization for heart failure Other all endpoints defined in ARC-25

—

Countries

Japan

Contacts

Public ContactYohei Sotomi

Osaka University Graduate School of Medicine Department of Cardiovascular Medicine

sotomiyohei@gmail.com06-6879-3631

Outcome results