Investigate how experiences such as childhood abuse and neglect alter brain activity in adulthood.

Investigating how social defeat stress in childhood causes changes in brain function in adulthood using questionnaires and magnetoencephalography. - Investigating how SDS in childhood causes changes in brain function in adulthood using questionnaires and MEG.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000053544

Enrollment

100

Registered

2024-04-01

Start date

2024-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adults

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy adults

Exclusion criteria

Exclusion criteria: pregnant dialysis patient taking neuromodulatory medication presence of a metal or electric implant history of neurological or psychiatric disorder

Design outcomes

Primary

Measure	Time frame
Resting brain activity will be measured using MEG. Furthermore, brain activity will be measured on a region-by-region basis with greater precision using MRI images of the individual. The Childhood Trauma Questionnaire-Short Form(CTQ-SF) will then be used to assess social defeat stress (SDS) experienced in childhood. The Brief Resilience Scale and the Connor-Davidson Resilience Scale will be used to assess stress tolerance. Additionally, the Beck Depression Inventory (BDI), a measure of depression, and the State-Trait Anxiety Inventory (STAI), a measure of anxiety, will be used to assess current mood. For pain assessment, thermal pain threshold and thermal pain tolerance threshold will be measured using a thermal stimulator.	—

Measure

Time frame

Resting brain activity will be measured using MEG. Furthermore, brain activity will be measured on a region-by-region basis with greater precision using MRI images of the individual. The Childhood Trauma Questionnaire-Short Form(CTQ-SF) will then be used to assess social defeat stress (SDS) experienced in childhood. The Brief Resilience Scale and the Connor-Davidson Resilience Scale will be used to assess stress tolerance. Additionally, the Beck Depression Inventory (BDI), a measure of depression, and the State-Trait Anxiety Inventory (STAI), a measure of anxiety, will be used to assess current mood. For pain assessment, thermal pain threshold and thermal pain tolerance threshold will be measured using a thermal stimulator.

—

Countries

Japan

Contacts

Public ContactSota Inoue

Niigata University of Health and Welfare Institute for Human Movement and Medical Science

hwd23015@nuhw.ac.jp025-257-4455

Outcome results