Male/Female adults
Conditions
Interventions
Consumption of a fermented milk drink (1 bottle a day) for 8 weeks.
Sponsors
Yakult Honsha Co., Ltd.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Males and females aged 20 to below 60 years at the time of consent acquisition. 2. Subjects who can give informed consent to partake in this study, after being provided with an explanation of the protocol detail.
Exclusion criteria
Exclusion criteria: 1. Subjects who experience abdominal symptoms (such as diarrhea, abdominal pain, bloating) upon consumption of dairy products. 2. Subjects who regularly use Food for Specified Health Uses (FOSHU), Foods with Function Claims, or health food (including supplements) more than twice a week, which may potentially affect the study and cannot discontinue them from the time of consent acquisition. 3. Subjects who are taking medications (such as antibiotics, Intestinal preparations, laxatives) more than twice a week, which may potentially affect the trial, and cannot restrict their use during the study period. 4. Subjects who excessive alcohol intake. 5. Subjects who smoke heavily (not less than 21 cigarettes a day) 6. Females who are pregnant or lactating, and females who could become pregnant or lactating during test period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression of activation markers on activated CD4+ T cells | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Immune cell composition of Peripheral Blood Mononuclear Cells. 2. Immune-related markers in plasma. 3. Immune-related markers in feces. 4. Metabolites in feces. 5. Background questionnaire on daily life 6. Daily questionnaire on test drink and health condition. | — |
Countries
Japan
Contacts
Public ContactTomoaki Naito
Yakult Honsha Co., Ltd. Yakult Central Institute
Outcome results
None listed