Male/female adults
Conditions
Interventions
Take 1 tablet of the test food
Take 1 tablet of the control food
Sponsors
EP Mediate Co., Ltd.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Japanese men and women aged 40 to below 65 years at the time of consent acquisition 2. Subjects with concerns about their oral environment 3. Preliminary examination will be conducted on 60 subjects, and those with high scores for "Cariogenic bacteria" and "Leukocyte" in the oral and saliva tests at the time of pre-test will be preferentially included. 4. Subjects who fully understand the purpose and content of the research and voluntarily agree to participate in the research
Exclusion criteria
Exclusion criteria: 1. Subjects who have visited a dentist within 10 days prior to the pre-test, those who are currently visiting a dentist for treatment of periodontal disease, dental caries and those who are scheduled to visit a dentist during the study period. 2. Subjects who routinely use dentures, mouthpieces, or other appliances that require removal and replacement, or orthodontic appliances. 3. Subjects who have undergone or are currently undergoing treatment for dental implants in the past, or who plan to undergo treatment during the research period. 4. Subjects who are judged to be unsuitable as research subjects (subjects) based on the results of preliminary examinations, such as those showing mouth ulcers. 5. Subjects used toothpaste containing hydroxyapatite within one month prior to the pre-test. 6. Subjects who have used mouthwash within one month prior to the pre-test. 7. Subjects who used an interdental brush within 1 month prior to the pre-test. 8. Subjects who have taken antibiotics (antimicrobials) within 3 months prior to the pre-test 9. Subjects who have had a fluoride rinse or application at a dental clinic within one month prior to the pre-test, or those who plan to have a rinse or application during the research period. 10. Subjects who have had abnormalities in clinical laboratory values or cardiopulmonary function and have been judged to be unsuitable for participation in the research. 11. Subjects at risk of developing allergies related to the research. 12. Subjects with a disease requiring constant medication (whether topical or oral), those with a disease under treatment (excluding dry eye and eye strain), and those with a history of a serious disease requiring medication treatment. 13. Subjects who work in shifts or late at night and have an irregular rhythm of life. 14. Subjects in other clinical studies, clinical trials, or human trials within one month prior to the start of this research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oral bacterial index | — |
Secondary
| Measure | Time frame |
|---|---|
| Oral bacterial flora Caries count, Salivary acidity, Buffering capacity of saliva, White blood cell count, Protein level, Ammonia concentration | — |
Countries
Japan
Contacts
Public ContactYoshimi Bansho
EP Mediate Co., Ltd. R&D Support Center Foods Department Section 1
Outcome results
None listed