Usefulness of the Perivascular Fat Attenuation Index in Acute Aortic Dissection

Usefulness of the Perivascular Fat Attenuation Index in Acute Aortic Dissection: A Multicenter Observational Cohort Study - AIDFAI (Aortic Inflammation Detection using Fat Attenuation Index in Acute Aortic Dissection) Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000053435

Enrollment

600

Registered

2024-01-25

Start date

2023-05-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute aortic dissection

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Regarding the diagnostic capability of the FAI, a retrospective, multicenter study was conducted involving consecutive patients from five institutions who underwent CT for chest or back pain. These institutions included the Department of Cardiovascular Medicine at the University of Tokyo Hospital (January 2018-June 2020), Sakakibara Heart Institute (January 2018-December 2021), Division of Cardiovascular Medicine at Saitama Medical Center, Jichi Medical University (May 2017-December 2021), Department of Cardiology at Tokyo Metropolitan Police Hospital (January 2019-December 2022), and Department of Cardiology at Kanto Central Hospital (January 2018-June 2021).

Exclusion criteria

Exclusion criteria: The patients who met the following criteria were excluded from the study: Patients with a previous history of AAD, trauma patients, individuals who did not undergo non-contrast CT, or those with poor image quality of scans due to implants or intra-aortic balloon pumping. Furthermore, individuals who were exposed to tube voltages other than 120 kVp were also excluded to maintain a consistent imaging protocol in the study. We excluded cases of aortic dissection limited to the ascending aorta, abdominal aorta, or aortic arch, as well as patients with aortic rupture and those who had undergone thoracic endovascular aortic repair (TEVAR). For the prognostic evaluation, the focus was on patients with type B AAD. Patients who underwent surgical interventions, including TEVAR and total arch replacement during their hospital stay, were excluded. Patients who died or experienced recurrent dissection during the same index hospitalization were also excluded, along with those who did not undergo follow-up CT during their hospitalization.

Design outcomes

Primary

Measure	Time frame
Diagnosis: The accuracy of the perivascular fat attenuation index in correctly diagnosing acute aortic dissection. Prognostication: The incidence of all-cause deaths and aortic events in patients with Stanford type B acute aortic dissection.	—

Countries

Japan

Contacts

Public ContactYusuke Adachi

The University of Tokyo Department of Cardiovascular Medicine, Graduate School of Medicine

yuadachi-tky@umin.ac.jp+81-3-3815-5411

Outcome results