Research on the involvement of protein-energy wasting and inflammation in the impact of serum albumin concentration and albumin leakage on survival in dialysis patients

Retrospective clinical study for the involvement of protein-energy wasting and inflammation in the impact of serum albumin concentration and albumin leakage on survival in patients on super high flux hemodialysis, super high flux-albumin-leaking hemodialysis, and online hemodiafiltration - Prognosis verification of PEW, inflammation, serum albumin concentration, and albumin leakage in patients with SHF-HD, SHF-albumin-leaking-HD, and OHDF

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000053304

Enrollment

700

Registered

2024-12-31

Start date

2024-01-16

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with end-stage kidney disease undergoing hemodialysis using dialyzers with beta2-microglobulin clearance of more than 70 mL/min and online hemodiafiltration

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients on maintenance hemodialysis or online hemodialysis as of July 1, 2017

Exclusion criteria

Exclusion criteria: 1 Use of dialyzers with beta2-microgloburln clearance below 70 mL/min 2 Missing data for covariates at study entry 3 Dialysis conditionssuch as dialysis method and membrane material between April 1, 2017 and June 30, 2017, which are different from those as of July 1, 2017 4 Blood purification methods other than HD 5 Dialysis frequency below 3 sessions per week or dialysis time below 3 hour per session 6 Pregnant or lactating patients

Design outcomes

Primary

Measure	Time frame
3-year all-cause mortality 1) High serum albumin concentration group vs. low serum albumin concentration group by median value 2) High albumin leakage group vs. low albumin leakage group by median value 3) High serum albumin concentration and high albumin leakage group vs. (1) Low serum albumin concentration and high albumin leakage group by median value (2) High serum albumin concentration and low albumin leakage group by median value (3) Low serum albumin concentration and low albumin leakage group by median value	—

Measure

Time frame

3-year all-cause mortality 1) High serum albumin concentration group vs. low serum albumin concentration group by median value 2) High albumin leakage group vs. low albumin leakage group by median value 3) High serum albumin concentration and high albumin leakage group vs. (1) Low serum albumin concentration and high albumin leakage group by median value (2) High serum albumin concentration and low albumin leakage group by median value (3) Low serum albumin concentration and low albumin leakage group by median value

—

Secondary

Measure	Time frame
3-year all-cause mortality 1) High serum albumin concentration group vs. low serum albumin concentration group by median value 2) High albumin leakage group vs. low albumin leakage group by median value 3) High serum albumin concentration and high albumin leakage group vs. (1) Low serum albumin concentration and high albumin leakage group by median value (2) High serum albumin concentration and low albumin leakage group by median value (3) Low serum albumin concentration and low albumin leakage group by median value	—

Measure

Time frame

—

Countries

Japan

Contacts

Public ContactKazuyoshi Okada

Social medical corporation, Kawashimakai, Kawashima hospital Department of Nephrology

m.tashiro@khg.or.jp088-631-0110

Outcome results