An exploratory study of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism frequencies in men and women of reproductive age

An exploratory study of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism frequencies in men and women of reproductive age - An exploratory study of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism frequencies in men and women of reproductive age

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000053294

Enrollment

1000

Registered

2024-02-01

Start date

2024-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Reproductive age Men and women suspected of infertility

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. have been fully informed of the purpose and content of the study, have the capacity to consent, and have volunteered to participate of their own free will with full understanding, and have agreed to participate in writing 2. Men and women must be at least 20 years of age at the time of participation.

Exclusion criteria

Exclusion criteria: Those deemed ineligible at the discretion of the principal investigator

Design outcomes

Primary

Measure	Time frame
genotype frequencies of the following MTHFR genotypes in men and women of reproductive age	—

Secondary

Measure	Time frame
Male: Semen analysis (semen volume, sperm concentration, motility), semen oxidation-reduction potential (sORP test), sperm DNA fragmentation index test (sperm DFI test) History of urological diseases and surgeries at the time of interview, sexual desire and sexual intercourse, SHIM diagnostic test results, etc. Measurement of serum folate and homocysteine Women Menstrual estrogen, progesterone, LH, FSH, PRL, AMH, etc. Results of questionnaires on menstruation, pregnancy, medications/medical history, surgical history, infertility treatment history, etc. at the time of interview Serum folate and homocysteine levels	—

Measure

Time frame

Male: Semen analysis (semen volume, sperm concentration, motility), semen oxidation-reduction potential (sORP test), sperm DNA fragmentation index test (sperm DFI test) History of urological diseases and surgeries at the time of interview, sexual desire and sexual intercourse, SHIM diagnostic test results, etc. Measurement of serum folate and homocysteine Women Menstrual estrogen, progesterone, LH, FSH, PRL, AMH, etc. Results of questionnaires on menstruation, pregnancy, medications/medical history, surgical history, infertility treatment history, etc. at the time of interview Serum folate and homocysteine levels

—

Countries

Japan

Contacts

Public ContactKiyotaka Kawai

Kameda IVF Clinic MAKUHARI Reproductive medicine

kawai.kiyotaka@kameda.jp81-43-296-8141

Outcome results