Multiple oral antibiotics therapy for induction and maintenance of ulcerative colitis

Multiple oral antibiotics therapy for induction and maintenance of ulcerative colitis - Multiple oral antibiotics therapy for ulcerative colitis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000053277

Enrollment

300

Registered

2024-01-05

Start date

2002-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ulcerative colitis

Interventions

amoxicillin 1500 mg t.i.d., tetracycline 1500 mg t.i.d., and metronidazole 750 mg t.i.d.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients were eligible if they had an established diagnosis of UC based on endoscopic, clinical and histological feature.

Exclusion criteria

Exclusion criteria: Exclusion criteria were penicillin allergy, administration of antibiotics agents within 2 weeks of study entry, ongoing biologic therapy, pregnancy, cancer and other serious comorbid illness. Patients who had stool pathogens including Clostridium difficile, Salmonellae, pathogenic Escherichia coli were also excluded.

Design outcomes

Primary

Measure	Time frame
The primary endpoint was the remission rate at 3 months after the completion of ATM therapy.	—

Countries

Japan

Contacts

Public ContactYuriko Nishikawa

Juntendo University Graduate School of Medicine Department of Microbiota Research

ynishika@juntendo.ac.jp0338133111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026