Healthy
Conditions
Interventions
Subjects take 10 g of jelly containing 30 ppm of hydrogen three times per day for 8 weeks.
Subjects take 10 g of jelly containing 30 ppm of air three times per day for 8 weeks.
Sponsors
Hiroshima University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Healthy males and females who constantly feel unsatisfaction with sleep quality 2) The average standardized score of five distinct factors in OSA-MA is under 45
Exclusion criteria
Exclusion criteria: 1) Under chronic diseases 2) Taking medicines or dietary supplements that may affect the trial 3) Participation in any clinical trial within three months of the commencement of the trial 4) In pregnancy or nursing a child 5) Judged as ineligible by the investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 8-week change in OSA-Sleep Inventory MA Version | — |
Secondary
| Measure | Time frame |
|---|---|
| 8-week changes in the following: Visual Analogue Scale (Sleep quality, Mental stress, Physical fatigue), Pittsburg Sleep Quality Index (PSQI), State-Trait Anxiety Inventory (STAI), Stool frequency, Gut microbiome, Oxidative stress and anti-oxidant markers (Urinary 8-hydroxy-2'-deoxyguanosine, Urinary isoprostanes, Serum oxidized/total coenzyme Q10 ratio, Serum LPO, Serum Fe, Serum Cu, Serum cholesterol, Serum triglyceride, Serum total antioxidant status, Serum uric acid, Serum vitamin C, Serum folic acid, Serum vitamin B12, Serum lutein and zeaxanthin, Serum beta-cryptoxanthin, Serum lycopene, Serum beta-carotene, Serum vitamin A, Serum alpha-tocopherol, Serum delta-tocopherol, Serum beta-gamma tocopherol, Serum alpha-tocopherol/cholesterol ratio, Serum ubiquinol) | — |
Countries
Japan
Contacts
Public ContactFumiko Higashikawa
Hiroshima University Hospital Medical Center for Translational and Clinical Research
Outcome results
None listed