The impact of aerobic exercise habits on total serum bilirubin levels and their implications as a mediator of anti-atherosclerosis mechanisms

The impact of aerobic exercise habits on total serum bilirubin levels and their implications as a mediator of anti-atherosclerosis mechanisms - The impact of aerobic exercise habits on total serum bilirubin levels and their implications as a mediator of anti-atherosclerosis mechanisms

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000053207

Enrollment

10000

Registered

2023-12-25

Start date

2023-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

annual health-checked participants

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Of 11,678 Japanese individuals over 18 years who underwent annual health checkups between April 2019 and March 2020 at the Health Planning Center of Nihon University Hospital,

Exclusion criteria

Exclusion criteria: We excluded 3,381 participants from the analysis according to the following criteria: unwillingness to provide informed consent for participation; positive history of ASCVD; leukocyte count more than 10000; C-reactive protein (CRP) level more than 3. 0 mg/dL; no record of frequency of fish consumption; presence of hepatitis B virus surface antigen, hepatitis C antibodies, liver cirrhosis, hepatocellular carcinoma, and metastatic liver cancer; or no measurement of white blood cell count, CRP levels, and TSB levels. We also excluded participants with TSB levels of more than 2.0 mg/dL to exclude constitutional jaundice as much as possible (i.e., the cut-off was to diagnose Gilbert syndrome in the absence of liver dysfunction). In addition, because there are cases in which TSB is higher in fasting blood samples than in random blood samples, we set the cut-off for TSB concentrations higher than the reference value

Design outcomes

Primary

Measure	Time frame
Comparisons of participant characteristics, laboratory profiles, and lifestyle behaviors between participants with aerobic exercise habits and those without aerobic exercise habits	—

Secondary

Measure	Time frame
Comparison of total serum bilirubin levels between participants with aerobic exercise habits or without aerobic exercise habits	—

Countries

Japan

Contacts

Public ContactShigemasa Tani

Nihon University Hospital Health Planning Center Nihon University Hospital Health Planning Center

tani.shigemasa@nihon-u.ac.jp09080537841

Outcome results