Exploratory Investigation of the Inhibitory Effect of Codium fragile Extract Lectin on Biofilm Formation on Human Tooth Surface

Exploratory Investigation of the Inhibitory Effect of Codium fragile Extract Lectin on Biofilm Formation on Human Tooth Surface - Inhibition of Dental Plaque Formation by Lectin from Seaweed "Codium fragile"

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000053076

Enrollment

Registered

2023-12-12

Start date

2024-01-23

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Biofilm Infection

Interventions

Mouthwash with 15 mL of test mouthwash (0.05% CPC solution containing 1% Codium fragile extract) for 30 seconds once. Mouthwash with 15 mL of control mouthwash (0.05% CPC solution without Codium fragi

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: For able-bodied persons

Exclusion criteria

Exclusion criteria: Allergic to any of the tested materials (if allergic symptoms occur) Pregnant or lactating mothers Other subjects who are judged to be ineligible by the investigator based on their schedule or dental disease status.

Design outcomes

Primary

Measure	Time frame
Change in the amount of bacteria on the tooth surface (calculated as ATP amount/area) after 6 hours	—

Secondary

Measure	Time frame
Changes in oral flora Changes in cariogenic bacteria count, acidity, buffer capacity, leukocyte count, protein, and ammonia in saliva Presence or absence of abnormal findings in the oral mucosa	—

Countries

Japan

Contacts

Public ContactShogo Takashiba

Okayama University Pathophysiology - Periodontal Science Faculty of Medicine, Dentistry and Pharmaceutical Sciences

stakashi@okayama-u.ac.jp086-235-6675

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026