How does the patient's blood exposed by cardiopulmonary bypass affect pancreatic cancer cells in human.

Study of cytokine kinetics in patient plasma under cardiopulmonary bypass and their effects on pancreatic cancer cells. - Effect of cardiopulmonary bypass on Pancreatic Cancer Cells

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000053046

Enrollment

Registered

2023-12-11

Start date

2023-12-12

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular disease requiring surgery with cardiopulmonary bypass.

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients who are between 20 and 65 years of age at the time of consent 2) Patients who have given a sufficient explanation of their participation in this study, and who have given written consent of their own free will based on a thorough understanding of the study. 3) Patients with an American Society of Anesthesiologists pre-anesthesia risk assessment of 4 or less (ASA classification 1: no organic, physiological, biochemical, or psychiatric abnormalities; 2: mild to moderate systematic disorder; 3: severe systematic disorder; 4: severe systematic disorder that is life-threatening and may not be curable even if surgery is performed; 5: severe systematic disorder that is life-threatening; 6: severe systematic disorder that is not curable even if surgery is performed; 7: severe systematic disorder that is not curable even if surgery is performed; 8: severe systematic disorder that is not curable even if surgery is performed. 5: A dying condition.)

Exclusion criteria

Exclusion criteria: 1) Patients with cancer or a history of surgery for malignant tumors 2) Patients with poorly controlled diabetes mellitus (HbA1c > 8.0%) 3) Patients with severe renal dysfunction (eGFR < 30%) 4)Patients with severe hepatic dysfunction (Child-Pugh C) 5) Patients taking steroids 6)Patients with inflammatory disease or infectious symptoms (surgical procedure for infective endocarditis) 7)Cases in which CPB is driven again, cases of circulatory arrest, and cases in which aortic blockade is not performed 8) Emergency surgery cases 9) Other patients deemed inappropriate as research subjects by the principal investigator 10) Patients who refuse to participate in this study.

Design outcomes

Primary

Measure	Time frame
Changes in plasma cytokines before and after use of cardiopulmonary bypass.	—

Secondary

Measure	Time frame
Investigation of proliferative, invasive and metastatic potential of pancreatic cancer cells using blood samples before and after the use of cardiopulmonary bypass.	—

Countries

Japan

Contacts

Public ContactSeidai Katagiri

Nihon University School of Medicine Department of Anesthesiology

katagiri.seidai@nihon-u.ac.jp03-3972-8111

Outcome results