Effect of toothpaste containing fennel extract on the oral environment of patients with periodontal disease

Effect of toothpaste containing fennel extract on the oral environment of patients with periodontal disease: a 4-week randomized controlled trial - A randomized controlled trial to examine effect of toothpaste containing fennel on periodontal disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000052974

Enrollment

Registered

2023-12-18

Start date

2023-12-18

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal disease

Interventions

Use of toothpaste containing fennel extract twice daily after meals, morning and evening, for four weeks Use of toothpaste placebo twice daily after meals, morning and evening, for four weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with periodontal disease who have more than 3 PPDs that are deeper than 5 mm 2. Patients who do not currently smoke 3. Patients with no food or drug allergies 4. Patients who have not taken any antimicrobial agents (including over-the-counter drugs) within 6 months prior to the date of enrollment.

Exclusion criteria

Exclusion criteria: 1. Patients who are pregnant or may be pregnant 2. Patients with uncontrolled diabetes, severe heart disease, renal dysfunction, hepatic dysfunction, etc. for which the dentist in charge deems inappropriate. 3. Patients who are taking antibody drugs or anti-inflammatory drugs for autoimmune diseases, etc.

Design outcomes

Primary

Measure	Time frame
The number of total bacteria and periodontal pathobionts in saliva and gingival crevicular fluid	—

Secondary

Measure	Time frame
1. Microbiota in saliva and gingival crevicular fluid 2. Probing pocket depth (PPD) 3. Clinical attachment loss (CAL) 4. Tooth mobility 5. Bleeding on probing (BOP) 6. Gingival index (GI) 7. Plaque index (PlI) 8. Plaque control record (PCR) 9. Periodontal epithelial surface area (PESA) 10. Periodontal inflamed surface area (PISA) 11. X-ray examination	—

Countries

Japan

Contacts

Public ContactYorimasa Ogata

Nihon University School of Dentistry at Matsudo Department of Periodontology

ogata.yorimasa@nihon-u.ac.jp047-368-6111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026