Osteoarthritis
Conditions
Interventions
None listed
Sponsors
Kawasaki Medical School
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: OA group Indication criteria 1) Patients scheduled for THA due to osteoarthritis of the hip joint. 2) Patients who understand the purpose and content of this study and have given written consent to participate in the study of their own free will. Fracture group Indication criteria 1) Patients undergoing surgery for artificial bone replacement due to femur fracture 2) Patients who understand the purpose and content of this study and have given written consent to participate in the study of their own free will. Normal group Indication criteria (1) Patients without pain that has persisted for more than 3 months 2) Patients between 20 and 80 years of age. (3) Persons who understand the purpose and content of this study and who have given written consent to participate in the study of their own free will.
Exclusion criteria
Exclusion criteria: OA group Exclusion criteria 1) Patients with severe pain in a location other than the hip joint (bilateral hip osteoarthritis is not excluded) 2) Patients with severe cognitive dysfunction (delirium, dementia, mental retardation, or other mental decline) at the time of preintervention evaluation. 3) Patients who have difficulty in communicating, reading, and writing in Japanese 4) Other subjects deemed inappropriate for this study by the principal investigator Fracture group Exclusion criteria 1) Patients with preoperative severe osteoarthritis of the hip joint 2) Patients with severe cognitive dysfunction (delirium, dementia, mental retardation, or other mental decline) at the time of preintervention evaluation 3) Patients who have difficulty in communicating, reading, and writing in Japanese. 4) Other subjects deemed inappropriate for this study by the principal investigator Normal group Exclusion Criteria 1) Patients with illnesses requiring immediate medical treatment 2) Persons with a history of alcohol or drug abuse or those who admit it at this time 3) Persons with a history of manic or psychotic states, or those who admit it at present 4) Persons who have or currently admit to having significant feelings of hopelessness 5) Those with strong cognitive impairment. 6) Those who have difficulty in communicating, reading, and writing in Japanese. 7) Others who the principal investigator deems inappropriate to participate in the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression levels of miRNAs in OA patients and healthy subjects | — |
Countries
Japan
Contacts
Public ContactHiroyuki Nishie
Kawasaki Medical School Department of Advanced Oncoloby
Outcome results
None listed